Modeling the effect of APC truncation on destruction complex function in colorectal cancer cells.
In colorectal cancer cells, APC, a tumor suppressor protein, is commonly expressed in truncated form. Truncation of APC is believed to disrupt degradation of β-catenin, which is regulated by a multiprotein complex called the destruction complex. The destruction complex comprises APC, Axin, β-catenin...
محفوظ في:
| المؤلفون الرئيسيون: | , |
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| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
Public Library of Science (PLoS)
2013-01-01
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| سلاسل: | PLoS Computational Biology |
| الوصول للمادة أونلاين: | http://europepmc.org/articles/PMC3784502?pdf=render |
| الوسوم: |
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