A general strategy to enhance the potency of chimeric transcriptional activators

Efforts to increase the potency of transcriptional activators are generally unsuccessful because poor expression of activators in mammalian cells limits their delivery to target promoters. Here we report that the effectiveness of chimeric activators can be dramatically improved by expressing them as...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Natesan, Sridaran, Molinari, Elizabeth, Rivera, Victor M., Rickles, Richard J., Gilman, Michael
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24162/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10570170/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.24.13898
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