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Apoptosis Induced by Aminoglycosides in LLC-PK1 Cells: Comparative Study of Neomycin, Gentamicin, Amikacin, and Isepamicin Using Electroporation

Levels of apoptosis induction (4′,6′-diamidino-2-phenylindole staining, activation of caspase 3) for aminoglycosides were compared by using renal LLC-PK1 cells. Amikacin caused less apoptosis than gentamicin in incubated cells. In electroporated cells, neomycin B and gentamicin caused apoptosis in t...

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Bibliographic Details
Main Authors: Denamur, Sophie, Van Bambeke, Françoise, Mingeot-Leclercq, Marie-Paule, Tulkens, Paul M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2415793/
https://ncbi.nlm.nih.gov/pubmed/18391041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01680-07
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