Gentamicin Causes Apoptosis at Low Concentrations in Renal LLC-PK(1) Cells Subjected to Electroporation

Gentamicin accumulates in the lysosomes of kidney proximal tubular cells and causes apoptosis at clinically relevant doses. Gentamicin-induced apoptosis can be reproduced with cultured renal cells, but only at high extracellular concentrations (1 to 3 mM; 0.4 to 1.2 g/liter) because of its low level...

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Главные авторы: Servais, Hélène, Jossin, Yves, Van Bambeke, Françoise, Tulkens, Paul M., Mingeot-Leclercq, Marie-Paule
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2006
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Mechanisms of Action: Physiological Effects
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1426926/
https://ncbi.nlm.nih.gov/pubmed/16569831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.4.1213-1221.2006
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