Fitness alteration of foot-and-mouth disease virus mutants: measurement of adaptability of viral quasispecies.

We document the rapid alteration of fitness of two foot-and-mouth disease virus (FMDV) mutants resistant to a neutralizing monoclonal antibody. Both mutants showed a selective disadvantage in BHK-21 cells when passaged in competition with their parental FMDV. Upon repeated replication of the mutants...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Martínez, M A, Carrillo, C, González-Candelas, F, Moya, A, Domingo, E, Sobrino, F
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1991
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC241436/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1645804/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.7.3954-3957.1991
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