CUL2 Is Required for the Activity of Hypoxia-inducible Factor and Vasculogenesis

CULLIN 2 (CUL2) is a component of the ElonginB/C-CUL2-RBX-1-Von Hippel-Lindau (VHL) tumor suppressor complex that ubiquitinates and degrades hypoxia-inducible factor α (HIFα). HIFα is a transcription factor that mediates the expression of hypoxia-sensitive genes, including vascular endothelial growt...

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Detalhes bibliográficos
Main Authors: Maeda, Yutaka, Suzuki, Takuji, Pan, Xiufang, Chen, Gang, Pan, Songqin, Bartman, Thomas, Whitsett, Jeffrey A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2414293/
https://ncbi.nlm.nih.gov/pubmed/18372249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710223200
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