Tyrosine replacement in P-selectin glycoprotein ligand-1 affects distinct kinetic and mechanical properties of bonds with P- and L-selectin

Selectins are adhesion molecules that initiate tethering and rolling of leukocytes on the vessel wall. Rolling requires rapid formation and breakage of selectin–ligand bonds that must have mechanical strength to resist premature dissociation by the forces applied in shear flow. P- and L-selectin bin...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Ramachandran, Vishwanath, Nollert, Matthias U., Qiu, Haiying, Liu, Wen-Jun, Cummings, Richard D., Zhu, Cheng, McEver, Rodger P.
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24140/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10570148/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.24.13771
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