Protection against lethal cytomegalovirus infection by a recombinant vaccine containing a single nonameric T-cell epitope.

The regulatory immediate-early (IE) protein pp89 of murine cytomegalovirus induces CD8+ T lymphocytes that protect against lethal murine cytomegalovirus infection. The IE1 epitope is the only epitope of pp89 that is recognized by BALB/c cytolytic T lymphocytes (CTL). Using synthetic peptides, the op...

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Bibliographic Details
Published in:J Virol
Main Authors: Del Val, M, Schlicht, H J, Volkmer, H, Messerle, M, Reddehase, M J, Koszinowski, U H
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1991
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC241372/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1710286/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.7.3641-3646.1991
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