Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network
A major activity of molecular chaperones is to prevent aggregation and refold misfolded proteins. However, when allowed to form, protein aggregates are refolded poorly by most chaperones. We show here that the sequential action of two Escherichia coli chaperone systems, ClpB and DnaK-DnaJ-GrpE, can...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
1999
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24133/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10570141/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.24.13732 |
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