Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network

A major activity of molecular chaperones is to prevent aggregation and refold misfolded proteins. However, when allowed to form, protein aggregates are refolded poorly by most chaperones. We show here that the sequential action of two Escherichia coli chaperone systems, ClpB and DnaK-DnaJ-GrpE, can...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Goloubinoff, Pierre, Mogk, Axel, Zvi, Anat Peres Ben, Tomoyasu, Toshifumi, Bukau, Bernd
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24133/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10570141/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.24.13732
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!