In vivo equilibrium of proinflammatory IL-17(+) and regulatory IL-10(+) Foxp3(+) RORγt(+) T cells

The nuclear hormone receptor retinoic acid receptor–related orphan receptor γt (RORγt) is required for the generation of T helper 17 cells expressing the proinflammatory cytokine interleukin (IL)-17. In vivo, however, less than half of RORγt(+) T cells express IL-17. We report here that RORγt(+) Tαβ...

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Détails bibliographiques
Auteurs principaux: Lochner, Matthias, Peduto, Lucie, Cherrier, Marie, Sawa, Shinichiro, Langa, Francina, Varona, Rosa, Riethmacher, Dieter, Si-Tahar, Mustapha, Di Santo, James P., Eberl, Gérard
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2008
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2413035/
https://ncbi.nlm.nih.gov/pubmed/18504307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080034
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