An antiinflammatory role for IKKβ through the inhibition of “classical” macrophage activation

The nuclear factor κB (NF-κB) pathway plays a central role in inflammation and immunity. In response to proinflammatory cytokines and pathogen-associated molecular patterns, NF-κB activation is controlled by IκB kinase (IKK)β. Using Cre/lox-mediated gene targeting of IKKβ, we have uncovered a tissue...

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Autors principals: Fong, Carol Ho Yan, Bebien, Magali, Didierlaurent, Arnaud, Nebauer, Ruth, Hussell, Tracy, Broide, David, Karin, Michael, Lawrence, Toby
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2008
Matèries:
Brief Definitive Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2413025/
https://ncbi.nlm.nih.gov/pubmed/18490491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080124
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