Attenuation of influenza A virus by insertion of a foreign epitope into the neuraminidase.
As the initial step in generating a live attenuated influenza A vaccine, we attempted to substitute an unrelated amino acid sequence (FLAG) for a portion of the neuraminidase (NA) molecule in influenza virus A/WSN/33 (H1N1), using a recently developed technique (reverse genetics [W. Luytjes, M. Krys...
Uloženo v:
| Vydáno v: | J Virol |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Microbiology (ASM)
1992
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC241288/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1378505/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.8.4647-4653.1992 |
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