Attenuation of influenza A virus by insertion of a foreign epitope into the neuraminidase.

As the initial step in generating a live attenuated influenza A vaccine, we attempted to substitute an unrelated amino acid sequence (FLAG) for a portion of the neuraminidase (NA) molecule in influenza virus A/WSN/33 (H1N1), using a recently developed technique (reverse genetics [W. Luytjes, M. Krys...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Castrucci, M R, Bilsel, P, Kawaoka, Y
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC241288/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1378505/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.8.4647-4653.1992
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