Attenuation of influenza A virus by insertion of a foreign epitope into the neuraminidase.

As the initial step in generating a live attenuated influenza A vaccine, we attempted to substitute an unrelated amino acid sequence (FLAG) for a portion of the neuraminidase (NA) molecule in influenza virus A/WSN/33 (H1N1), using a recently developed technique (reverse genetics [W. Luytjes, M. Krys...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Castrucci, M R, Bilsel, P, Kawaoka, Y
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1992
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC241288/
https://ncbi.nlm.nih.gov/pubmed/1378505
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk