Phenotypes of Epstein-Barr virus LMP1 deletion mutants indicate transmembrane and amino-terminal cytoplasmic domains necessary for effects in B-lymphoma cells.

Eitemau Tebyg

• The last seven transmembrane and carboxy-terminal cytoplasmic domains of Epstein-Barr virus latent membrane protein 2 (LMP2) are dispensable for lymphocyte infection and growth transformation in vitro.
  gan: Longnecker, R, et al.
  Cyhoeddwyd: (1993)
• Epstein-Barr virus recombinant molecular genetic analysis of the LMP1 amino-terminal cytoplasmic domain reveals a probable structural role, with no component essential for primary B-lymphocyte growth transformation.
  gan: Izumi, K M, et al.
  Cyhoeddwyd: (1994)
• A second Epstein-Barr virus membrane protein (LMP2) is expressed in latent infection and colocalizes with LMP1.
  gan: Longnecker, R, et al.
  Cyhoeddwyd: (1990)
• The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation; fibroblast cocultivation complements a critical function within the terminal 155 residues.
  gan: Kaye, K M, et al.
  Cyhoeddwyd: (1995)
• Epstein-Barr virus latent infection membrane protein alters the human B-lymphocyte phenotype: deletion of the amino terminus abolishes activity.
  gan: Wang, D, et al.
  Cyhoeddwyd: (1988)