Pharmacokinetic behaviour of the chemoprotectants BNP7787 and mesna after an i.v. bolus injection in rats

In preclinical studies, BNP7787 (disodium 2,2′-dithio-bis-ethane sulphonate), the disulphide form of mesna, has demonstrated selective protection against cisplatin-induced nephrotoxicity due to conversion into mesna inactivating toxic platinum species. Mesna (sodium 2-mercapto ethane sulphonate), ho...

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Main Authors: Verschraagen, M, Boven, E, Torun, E, Erkelens, C A M, Hausheer, F H, van der Vijgh, W J F
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2004
Teme:
Experimental Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2410273/
https://ncbi.nlm.nih.gov/pubmed/15083199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601719
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