Novel covalent modification of human anaplastic lymphoma kinase (ALK) and potentiation of crizotinib-mediated inhibition of ALK activity by BNP7787

BNP7787 (Tavocept, disodium 2,2′-dithio-bis-ethanesulfonate) is a novel, investigational, water-soluble disulfide that is well-tolerated and nontoxic. In separate randomized multicenter Phase II and Phase III clinical trials in non-small-cell lung cancer (NSCLC) patients, treatment with BNP7787 in c...

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Bibliografiset tiedot
Julkaisussa:Onco Targets Ther
Päätekijät: Parker, Aulma R, Petluru, Pavankumar N, Nienaber, Vicki L, Zhao, Min, Ayala, Philippe Y, Badger, John, Chie-Leon, Barbara, Sridhar, Vandana, Logan, Cheyenne, Kochat, Harry, Hausheer, Frederick H
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Dove Medical Press 2015
Aiheet:
Original Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324543/
https://ncbi.nlm.nih.gov/pubmed/25678804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S73690
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