Tyrosine kinase inhibitor AG1024 exerts antileukaemic effects on STI571-resistant Bcr-Abl expressing cells and decreases AKT phosphorylation

Chronic myelogenous leukaemia (CML) is a clonal malignancy of the pluripotent haematopoietic stem cell, characterised by an uncontrolled proliferation and expansion of myeloid progenitors expressing a fusion oncogene, BCR-ABL, the molecular counterpart of the Ph1 chromosome. The tyrosine kinase (TK)...

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Detalhes bibliográficos
Main Authors: Deutsch, E, Maggiorella, L, Wen, B, Bonnet, M L, Khanfir, K, Frascogna, V, Turhan, A G, Bourhis, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409959/
https://ncbi.nlm.nih.gov/pubmed/15494718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602190
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