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Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer

mTOR is a downstream mediator in the PI3K/Akt signalling pathway, which plays a critical role in regulating basic cellular functions. These include cell proliferation, survival, mobility and angiogenesis. Rapamycin and its analogues (CCI-779, RAD001 and AP23573) have specific antagonistic action on...

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Detalhes bibliográficos
Autor principal: Chan, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409926/
https://ncbi.nlm.nih.gov/pubmed/15365568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602162
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