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Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer
mTOR is a downstream mediator in the PI3K/Akt signalling pathway, which plays a critical role in regulating basic cellular functions. These include cell proliferation, survival, mobility and angiogenesis. Rapamycin and its analogues (CCI-779, RAD001 and AP23573) have specific antagonistic action on...
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| Hovedforfatter: | |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2409926/ https://ncbi.nlm.nih.gov/pubmed/15365568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602162 |
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