Inherent growth advantage of (pre)malignant hepatocytes associated with nuclear translocation of pro-transforming growth factor α

The pro-peptide of transforming growth factor α (proTGFα) was recently found in hepatocyte nuclei preparing for DNA replication, which suggests a role of nuclear proTGFα for mitogenic signalling. This study investigates whether the nuclear occurrence of the pro-peptide is involved in the altered gro...

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Main Authors: Schausberger, E, Hufnagl, K, Parzefall, W, Gerner, C, Kandioler-Eckersberger, D, Wrba, F, Klimpfinger, M, Schulte-Hermann, R, Grasl-Kraupp, B
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2004
Assuntos:
Experimental Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409777/
https://ncbi.nlm.nih.gov/pubmed/15534611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602191
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