Impact of antibody framework residue V(H)-71 on the stability of a humanised anti-MUC1 scFv and derived immunoenzyme

Anti-MUC1 single-chain Fv (scFv) fragments generated from the humanised antibody huHMFG1 had adequate antigen-binding properties but very poor stability irrespective of the applied linker or domain orientation. Mutagenesis of heavy-chain framework residue V(H)-71, previously described as a key resid...

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Detalhes bibliográficos
Main Authors: Krauss, J, Arndt, M A E, Zhu, Z, Newton, D L, Vu, B K, Choudhry, V, Darbha, R, Ji, X, Courtenay-Luck, N S, Deonarain, M P, Richards, J, Rybak, S M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409732/
https://ncbi.nlm.nih.gov/pubmed/15150594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601759
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