Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice

We examined the antitumour effect of a combination of betulinic acid (BA) and vincristine (VCR) on murine melanoma B16F10 cells in vitro and in vivo. Betulinic acid, a pentacyclic triterpene, showed a synergistic cytotoxic effect on melanoma cells by combinational use of VCR. Betulinic acid and VCR...

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Main Authors: Sawada, N, Kataoka, K, Kondo, K, Arimochi, H, Fujino, H, Takahashi, Y, Miyoshi, T, Kuwahara, T, Monden, Y, Ohnishi, Y
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2004
Teme:
Experimental Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409700/
https://ncbi.nlm.nih.gov/pubmed/15083202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601746
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