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Improved biological activity of a mutant endostatin containing a single amino-acid substitution

Human endostatin has an internal Asn-Gly-Arg (NGR) motif at position 126–128 following a proline at position 125. Asn-Gly-Arg-containing peptides have been shown to target tumour vasculature and inhibit aminopeptidase N activity. We previously compared the in vitro and in vivo biological activities...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Yokoyama, Y, Ramakrishnan, S
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2004
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409698/
https://ncbi.nlm.nih.gov/pubmed/15083196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601745
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