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Improved biological activity of a mutant endostatin containing a single amino-acid substitution
Human endostatin has an internal Asn-Gly-Arg (NGR) motif at position 126–128 following a proline at position 125. Asn-Gly-Arg-containing peptides have been shown to target tumour vasculature and inhibit aminopeptidase N activity. We previously compared the in vitro and in vivo biological activities...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2409698/ https://ncbi.nlm.nih.gov/pubmed/15083196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601745 |
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