Modifying an immunogenic epitope on a therapeutic protein: a step towards an improved system for antibody-directed enzyme prodrug therapy (ADEPT)

Carboxypeptidase G2 (CP) is a bacterial enzyme, which is targeted to tumours by an antitumour antibody for local prodrug activation in antibody-directed enzyme prodrug therapy (ADEPT). Repeated cycles of ADEPT are desirable but are hampered by human antibody response to CP (HACA). To address this, w...

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Detalhes bibliográficos
Main Authors: Mayer, A, Sharma, S K, Tolner, B, Minton, N P, Purdy, D, Amlot, P, Tharakan, G, Begent, R H J, Chester, K A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409521/
https://ncbi.nlm.nih.gov/pubmed/15162148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601888
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