Plasma clearance of an antibody--enzyme conjugate in ADEPT by monoclonal anti-enzyme: its effect on prodrug activation in vivo.

The effect of anti-enzyme antibody clearance on prodrug turnover in antibody-directed enzyme prodrug therapy (ADEPT) has been studied. Mice bearing LS174T xenografts were given localising carboxypeptidase G2 (CPG)2 conjugate (AEC) and 19 h later galactosylated anti-CPG2 antibody (SB43-GAL). In regim...

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Autors principals: Rogers, G. T., Burke, P. J., Sharma, S. K., Koodie, R., Boden, J. A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1995
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034085/
https://ncbi.nlm.nih.gov/pubmed/8519645
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