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Use of suppressor analysis to identify DNA polymerase mutations in herpes simplex virus which affect deoxynucleoside triphosphate substrate specificity.

Herpes simplex virus DNA polymerase mutations which map in the N-terminal part of the protein and appear to alter deoxynucleoside triphosphate (dNTP) substrate specificity are described. These mutations suppress a drug hypersensitivity associated with the downstream mutation, Aphr10. We suggest that...

詳細記述

保存先:
書誌詳細
出版年:J Virol
主要な著者: Wang, Y S, Woodward, S, Hall, J D
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 1992
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240950/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1310785/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.3.1814-1816.1992
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