Electrostatic basis for the unidirectionality of the primary proton transfer in cytochrome c oxidase

Gaining detailed understanding of the energetics of the proton-pumping process in cytochrome c oxidase (CcO) is one of the challenges of modern biophysics. Despite promising mechanistic proposals, most works have not related the activation barriers of the different assumed steps to the protein struc...

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Hauptverfasser: Pisliakov, Andrei V., Sharma, Pankaz K., Chu, Zhen T., Haranczyk, Maciej, Warshel, Arieh
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409407/
https://ncbi.nlm.nih.gov/pubmed/18509049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800580105
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