Local IGFBP-3 mRNA expression, apoptosis and risk of colorectal adenomas

BACKGROUND: IGF binding protein-3 (IGFBP-3) regulates the bioavailability of insulin-like growth factors I and II, and has both anti-proliferative and pro-apoptotic properties. Elevated plasma IGFBP-3 has been associated with reduced risk of colorectal cancer (CRC), but the role of tissue IGFBP-3 is...

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Autores principales: Keku, Temitope O, Sandler, Robert S, Simmons, James G, Galanko, Joseph, Woosley, John T, Proffitt, Michelle, Omofoye, Oluwaseun, McDoom, Maya, Lund, Pauline K
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409350/
https://ncbi.nlm.nih.gov/pubmed/18498652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-143
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