The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity

Monocarboxylate transporters MCT1-MCT4 require basigin (CD147) or embigin (gp70), ancillary proteins with a glutamate residue in their single transmembrane (TM) domain, for plasma membrane (PM) expression and activity. Here we use site-directed mutagenesis and expression in COS cells or Xenopus oocy...

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Main Authors: Manoharan, Christine, Wilson, Marieangela C., Sessions, Richard B., Halestrap, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado: Informa Healthcare 2006
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409183/
https://ncbi.nlm.nih.gov/pubmed/17127621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/09687860600841967
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