HDAC Inhibitors Act with 5-aza-2′-Deoxycytidine to Inhibit Cell Proliferation by Suppressing Removal of Incorporated Abases in Lung Cancer Cells

5-aza-2′-deoxycytidine (5-aza-CdR) is used extensively as a demethylating agent and acts in concert with histone deacetylase inhibitors (HDACI) to induce apoptosis or inhibition of cell proliferation in human cancer cells. Whether the action of 5-aza-CdR in this synergistic effect results from demet...

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Detalhes bibliográficos
Main Authors: Chai, Guolin, Li, Lian, Zhou, Wen, Wu, Lipeng, Zhao, Ying, Wang, Donglai, Lu, Shaoli, Yu, Yu, Wang, Haiying, McNutt, Michael A., Hu, Ye-Guang, Chen, Yingqi, Yang, Yang, Wu, Xin, Otterson, Gregory A., Zhu, Wei-Guo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409077/
https://ncbi.nlm.nih.gov/pubmed/18560576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002445
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