A non-toxic ligand for voxel-based MRI analysis of plaques in AD transgenic mice

Amyloid plaques are a characteristic feature in Alzheimer’s disease (AD). A novel non-toxic contrast agent is presented, Gd-DTPA-K6Aβ1–30, which is homologous to Aβ, and allows plaque detection in vivo. μMRI was performed on AD model mice and controls prior to and following intra-carotid injection w...

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Detalhes bibliográficos
Main Authors: Sigurdsson, Einar M., Wadghiri, Youssef Z., Mosconi, Lisa, Blind, Jeffrey A., Knudsen, Elin, Asuni, Ayodeji, Scholtzova, Henrieta, Tsui, Wai H., Li, Yongsheng, Sadowski, Martin, Turnbull, Daniel H., de Leon, Mony J., Wisniewski, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2408732/
https://ncbi.nlm.nih.gov/pubmed/17291630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2006.12.018
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