Mouse-Passaged Severe Acute Respiratory Syndrome-Associated Coronavirus Leads to Lethal Pulmonary Edema and Diffuse Alveolar Damage in Adult but Not Young Mice

Advanced age is a risk factor of severe acute respiratory syndrome (SARS) in humans. To understand its pathogenesis, we developed an animal model using BALB/c mice and the mouse-passaged Frankfurt 1 isolate of SARS coronavirus (SARS-CoV). We examined the immune responses to SARS-CoV in both young an...

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Main Authors: Nagata, Noriyo, Iwata, Naoko, Hasegawa, Hideki, Fukushi, Shuetsu, Harashima, Ayako, Sato, Yuko, Saijo, Masayuki, Taguchi, Fumihiro, Morikawa, Shigeru, Sata, Tetsutaro
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2008
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Regular Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2408422/
https://ncbi.nlm.nih.gov/pubmed/18467696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.071060
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