Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid

The exceptional sensitivity of Mycobacterium tuberculosis to isonicotinic acid hydrazide (INH) lacks satisfactory definition. M. tuberculosis is a natural mutant in oxyR, a central regulator of peroxide stress response. The ahpC gene, which encodes a critical subunit of alkyl hydroperoxide reductase...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Zhang, Y., Dhandayuthapani, S., Deretic, V.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1996
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24072/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8917570/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.23.13212
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