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Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid

The exceptional sensitivity of Mycobacterium tuberculosis to isonicotinic acid hydrazide (INH) lacks satisfactory definition. M. tuberculosis is a natural mutant in oxyR, a central regulator of peroxide stress response. The ahpC gene, which encodes a critical subunit of alkyl hydroperoxide reductase...

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Bibliografske podrobnosti
Main Authors: Zhang, Y., Dhandayuthapani, S., Deretic, V.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences of the USA 1996
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC24072/
https://ncbi.nlm.nih.gov/pubmed/8917570
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