The viral transcriptional regulatory region upstream of the E6 and E7 genes is a major determinant of the differential immortalization activities of human papillomavirus types 16 and 18.

The human papillomavirus types 16 (HPV-16) and 18 (HPV-18) can immortalize primary human keratinocytes. The region of the viral genome responsible for this function maps to the E6 and E7 genes and their respective upstream transcriptional regulatory sequences, the long control regions (LCRs). The HP...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Romanczuk, H, Villa, L L, Schlegel, R, Howley, P M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240641/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1850048/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.5.2739-2744.1991
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