Concomitant combination therapy for HIV infection preferable over sequential therapy with 3TC and non-nucleoside reverse transcriptase inhibitors

Exposure to 3TC of HIV-1 mutant strains containing non-nucleoside reverse transcriptase inhibitor (NNRTI)-specific mutations in their reverse transcriptase (RT) easily selected for double-mutant viruses that had acquired the characteristic 184-Ile mutation in their RT in addition to the NNRTI-specif...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Balzarini, Jan, Pelemans, Heidi, Karlsson, Anna, De Clercq, Erik, Kleim, Jörg-Peter
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1996
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24062/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8917560/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.23.13152
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