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Concomitant combination therapy for HIV infection preferable over sequential therapy with 3TC and non-nucleoside reverse transcriptase inhibitors

Exposure to 3TC of HIV-1 mutant strains containing non-nucleoside reverse transcriptase inhibitor (NNRTI)-specific mutations in their reverse transcriptase (RT) easily selected for double-mutant viruses that had acquired the characteristic 184-Ile mutation in their RT in addition to the NNRTI-specif...

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Autori principali: Balzarini, Jan, Pelemans, Heidi, Karlsson, Anna, De Clercq, Erik, Kleim, Jörg-Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences of the USA 1996
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC24062/
https://ncbi.nlm.nih.gov/pubmed/8917560
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