Identification of neutralizing antigenic sites on VP1 and VP2 of type A5 foot-and-mouth disease virus, defined by neutralization-resistant variants.

Five neutralizing monoclonal antibodies (nMAbs) obtained against type A5 Spain-86 foot-and-mouth disease virus were used to generate a series of neutralization-resistant variants. In vitro and in vivo assays showed that the variants were fully refractory to neutralization by the selecting nMAb. On t...

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Udgivet i:J Virol
Main Authors: Saiz, J C, Gonzalez, M J, Borca, M V, Sobrino, F, Moore, D M
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240607/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1707983/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.5.2518-2524.1991
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