In vitro enzymatic activity of human immunodeficiency virus type 1 reverse transcriptase mutants in the highly conserved YMDD amino acid motif correlates with the infectious potential of the proviral genome.

Reverse transcriptases contain a highly conserved YXDD amino acid motif believed to be important in enzyme function. The second amino acid is not strictly conserved, with a methionine, valine or alanine occupying the second position in reverse transcriptases from various retroviruses and retroelemen...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Wakefield, J K, Jablonski, S A, Morrow, C D
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240183/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1383571/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.11.6806-6812.1992
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