Mutation of the aspartic acid residues of the GDD sequence motif of poliovirus RNA-dependent RNA polymerase results in enzymes with altered metal ion requirements for activity.

Eitemau Tebyg

• Enzymatic activity of poliovirus RNA polymerases with mutations at the tyrosine residue of the conserved YGDD motif: isolation and characterization of polioviruses containing RNA polymerases with FGDD and MGDD sequences.
  gan: Jablonski, S A, et al.
  Cyhoeddwyd: (1993)
• Enzymatic activity of poliovirus RNA polymerase mutants with single amino acid changes in the conserved YGDD amino acid motif.
  gan: Jablonski, S A, et al.
  Cyhoeddwyd: (1991)
• Mutation Analysis of the GDD Sequence Motif of a Calicivirus RNA-Dependent RNA Polymerase
  gan: Vázquez, Ana López, et al.
  Cyhoeddwyd: (2000)
• An aspartic acid at amino acid 108 is required to rescue infectious virus after transfection of a poliovirus cDNA containing a CGDD but not SGDD amino acid motif in 3Dpol.
  gan: Walker, D E, et al.
  Cyhoeddwyd: (1995)
• Conserved aspartic acid 233 and alanine 231 are not required for poliovirus polymerase function in replicons
  gan: Freistadt, Marion S, et al.
  Cyhoeddwyd: (2007)