The only domain which distinguishes Epstein-Barr virus latent membrane protein 2A (LMP2A) from LMP2B is dispensable for lymphocyte infection and growth transformation in vitro; LMP2A is therefore nonessential.

Using second-site homologous recombination, Epstein-Barr virus (EBV) recombinants were constructed which carry an LMP2A mutation terminating translation at codon 19. Despite the absence of LMP2A or LMP2A cross-reactive protein, the recombinants were able to initiate and maintain primary B-lymphocyte...

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Bibliographic Details
Published in:J Virol
Main Authors: Longnecker, R, Miller, C L, Miao, X Q, Marchini, A, Kieff, E
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240138/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1328675/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.11.6461-6469.1992
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