Protein phosphatase 2A dephosphorylates simian virus 40 large T antigen specifically at residues involved in regulation of DNA-binding activity.

Treatment of purified simian virus 40 large T antigen (LT) with protein phosphatase 2A stimulates LT-dependent DNA unwinding and replication (D. M. Virshup, M. G. Kauffman, and T. J. Kelly, EMBO J. 8: 3891-3898, 1989). The specificity of the catalytic subunit of protein phosphatase 2A toward LT was...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Scheidtmann, K H, Virshup, D M, Kelly, T J
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240073/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1848320/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.4.2098-2101.1991
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