Alteration of the pH dependence of coronavirus-induced cell fusion: effect of mutations in the spike glycoprotein.

Infection of susceptible murine cells with the coronavirus mouse hepatitis virus type 4 (MHV4) results in extensive cell-cell fusion at pHs from 5.5 to 8.5. The endosomotropic weak bases chloroquine and ammonium chloride do not prevent MHV4 infection. In marked contrast, we have selected variants fr...

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Pubblicato in:	J Virol
Autori principali:	Gallagher, T M, Escarmis, C, Buchmeier, M J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240014/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1848311/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.4.1916-1928.1991
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