Concanavalin A targets phylogenetically conserved N-linked glycans on coronavirus spike proteins for broad-spectrum antiviral activity

ABSTRACT The rapid evolution of SARS-CoV-2 variants, driven by antigenic drift in the spike glycoprotein, continues to undermine the efficacy of current vaccines and monoclonal antibody therapies. Targeting conserved features of the spike protein has been a major focus against coronavirus entry and...

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ग्रंथसूची विवरण

मुख्य लेखकों:	Dekuan Guo, Shi Yu, Kaixiong Ma, Hua Tao, Qingxing Wang, Sirui Han, Qiangyun Ai, Huina Hu, Xiancai Ma, Geng Li, Shaobo Wang
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	American Society for Microbiology 2026-05-01
श्रृंखला:	Journal of Virology
विषय:	coronavirus viral entry spike glycoprotein lectin N-linked glycosylation
ऑनलाइन पहुंच:	https://journals.asm.org/doi/10.1128/jvi.01679-25
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