Naturally occurring missense mutation in the polymerase gene terminating hepatitis B virus replication.

A hepatitis B virus (HBV) genome was cloned from human liver. Numerous mutations in all viral genes define this HBV DNA as a mutant, divergent from all known HBV DNA sequences. Functional analyses of this mutant demonstrated a defect blocking viral DNA synthesis. The genetic basis of this defect was...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Blum, H E, Galun, E, Liang, T J, von Weizsäcker, F, Wands, J R
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC239993/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2002544/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.4.1836-1842.1991
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