A second-site revertant of a defective herpes simplex virus ICP4 protein with restored regulatory activities and impaired DNA-binding properties.

A mutant of herpes simplex virus type 1, vi12, encodes a DNA-binding- and transactivation-deficient ICP4 polypeptide. Because of the mutation, the vi12 virus does not grow on Vero cells but must be propagated on cells that express complementing levels of wild-type ICP4 (E5 cells). A pseudorevertant...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Shepard, A A, DeLuca, N A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC239818/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1846199/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.2.787-795.1991
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