Involvement of a specificity proteins-binding element in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene

INTRODUCTION: Increased estrogen level has been regarded to be a risk factor for breast cancer. However, estrogen has also been shown to induce the expression of the tumor suppressor gene, BRCA1. Upregulation of BRCA1 is thought to be a feedback mechanism for controlling DNA repair in proliferating...

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Main Authors: Hockings, Jennifer K, Degner, Stephanie C, Morgan, Sherif S, Kemp, Michael Q, Romagnolo, Donato F
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2008
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2397528/
https://ncbi.nlm.nih.gov/pubmed/18377656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr1987
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