A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

The embryonic programme ‘epithelial–mesenchymal transition' (EMT) is thought to promote malignant tumour progression. The transcriptional repressor zinc-finger E-box binding homeobox 1 (ZEB1) is a crucial inducer of EMT in various human tumours, and was recently shown to promote invasion and me...

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Bibliographic Details
Main Authors: Burk, Ulrike, Schubert, Jörg, Wellner, Ulrich, Schmalhofer, Otto, Vincan, Elizabeth, Spaderna, Simone, Brabletz, Thomas
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2008
Subjects:
Scientific Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396950/
https://ncbi.nlm.nih.gov/pubmed/18483486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.74
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