Complement-Mediated Dysfunction of Glomerular Filtration Barrier Accelerates Progressive Renal Injury

Intrarenal complement activation leads to chronic tubulointerstitial injury in animal models of proteinuric nephropathies, making this process a potential target for therapy. This study investigated whether a C3-mediated pathway promotes renal injury in the protein overload model and whether the abn...

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Bibliografische gegevens
Hoofdauteurs: Abbate, Mauro, Zoja, Carla, Corna, Daniela, Rottoli, Daniela, Zanchi, Cristina, Azzollini, Nadia, Tomasoni, Susanna, Berlingeri, Silvia, Noris, Marina, Morigi, Marina, Remuzzi, Giuseppe
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Nephrology 2008
Onderwerpen:
Basic Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396931/
https://ncbi.nlm.nih.gov/pubmed/18354030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2007060686
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