PDGF-C Is a Proinflammatory Cytokine that Mediates Renal Interstitial Fibrosis

PDGF-C is a potent mitogen for fibroblasts in vitro. Transgenic PDGF-C overexpression in the heart or liver induces organ fibrosis, and PDGF-C expression is upregulated at sites of interstitial fibrosis in human and rat kidneys; however, the effect of inhibiting PDGF-C on the development of renal fi...

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Autori principali: Eitner, Frank, Bücher, Eva, van Roeyen, Claudia, Kunter, Uta, Rong, Song, Seikrit, Claudia, Villa, Luigi, Boor, Peter, Fredriksson, Linda, Bäckström, Gudrun, Eriksson, Ulf, Östman, Arne, Floege, Jürgen, Ostendorf, Tammo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2008
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396746/
https://ncbi.nlm.nih.gov/pubmed/18184860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2007030290
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