A PAI-1 Mutant, PAI-1R, Slows Progression of Diabetic Nephropathy

Plasminogen activator inhibitor-1 (PAI-1) has been implicated in renal fibrosis. In vitro, PAI-1 inhibits plasmin generation, and this decreases mesangial extracellular matrix turnover. PAI-1R, a mutant PAI-1, increases glomerular plasmin generation, reverses PAI-1 inhibition of matrix degradation,...

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Bibliographic Details
Main Authors: Huang, Yufeng, Border, Wayne A., Yu, Ling, Zhang, Jiandong, Lawrence, Daniel A., Noble, Nancy A.
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2008
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396741/
https://ncbi.nlm.nih.gov/pubmed/18216319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2007040510
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